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郑宜君课题组介绍

课题组长 Group Leader 丨研究介绍 Research Interest 丨代表性论文 Select Publications 丨本组成员 Group Members丨组内活动 Group activities

郑宜君 Yijun Zheng，助理教授、研究员 Assistant Professor, PI
通讯地址 Office Address：上海市浦东新区华夏中路393号bat365中文官方网站3号楼
电子邮件 Email：zhengyj@shanghaitech.edu.cn

11/2019~now, Assistant Professor at ShanghaiTech University, China
10/2015~10/2019, Postdoc at INM-Leibniz Institute for New Materials, Germany
8/2011~9/2013, Postdoc at MPI for Polymer Research, Germany

Ph.D. at Peking University (Sept. 2006-Jul. 2011), China 导师：宛新华

Visiting student at University of South Carolina (Jan. 2010-Jun. 2010), USA, 导师：唐传兵

Bachelor at Beijing Normal University (Sept. 2002-Jul. 2006), China 导师：刘正平

研究介绍

Research Interest

Our research focus on developing advanced dynamic biomaterials mimicking extracellular matrix to understand how cells interact with their environment and to gain insight into the manipulating mechanism of cell functions.

In the current stage, we are particularly interested on two topics:

(1) Molecular tools for cellular mechanosensing.

One of the central challenges in cellular mechanotransduction is the understanding of the molecular mechanisms that enable cells to modulate their mechanical responses and to sense and actively direct the biophysical properties of the ECM. To elucidate these fundamental mechanisms, cellular mechanotransduction should be studied at molecular levels. We develop molecular tools that can apply or detect forces at individual receptors within readily formed cell-ECM or cell-cell contacts.

(2) Synthetic yet 'living' biomaterials with active, adaptive and autonomous properties.

We established ways to emulate “living” properties within synthetic chemical frameworks through non-equilibrium chemical reaction networks with energy dissipation, kinetic control and feedback loops.

Welcome undergrads and graduate students with different backgrounds to join the group. We are recruiting POSTDOCs (with organic chemistry, polymer chemistry or biomaterials background). Feel free to contact the PI.

代表性论文

Select Publications

1. P. Zhao#, L. Xu#, B. Li, Y. Zhao, Y. Zhao, Y. Lu, M. Cao, G. Li, T. Weng, H. Wang, Y. Zheng*, Non-Equilibrium Assembly of Atomically-Precise Copper Nanoclusters, Adv. Mater. 2024, 2311818.

2. Y. Zhao#, P. Zhao#, J. Zhang#, Y. Zhao, B. Li, G. Hao, Y. An, W. Zhou, Y. Lu, L. Chou, Y. Zheng*, CCS Chem. 2023, 5, 1-11.

3. W. Zhou#, G. Shi#, P. Zhao, G. Zhang, P. Yang, B. Li, B. Li, X. Wan*, Y. Zheng*, Dynamic helical cationic polyacetylenes for fast and highly efficient killing of bacteria, Acta Biomater, Doi: 10.1016/j.actbio.2023.02.017.

4. N. Cheng, Y. Zhang, Y. Wu, B. Li, H. Wang, S. Chen, P. Zhao, J. Cui, X. Shen, X. Zhu, Y. Zheng*, Hydrogel platform capable of molecularly resolved pulling on cells for mechanotransduction, Material Today Bio, 2022,17,100476.

5. J. Zhang, J. Liu, H. Li, X. Li, Y. Zhao, P. Zhao, J. Cui, B. Yang, Y. Song, Y. Zheng*, Programming hydrogels with complex transient behaviors via autocatalytic cascade reactions, ACS Appl. Mater. Interfaces 2022, 14, 17, 20073–20082.

6. J. Feng, Y. Zheng, Q. Jiang, M.K.Wlodarczyk-Biegun, S. Person, A. del Campo, Elastomeric optical waveguides by extrusion printing, Advanced Materials Technologies, 2022, 2101539.

7. B. Li, J. Blass, M. Han, J. Zhang, Y. Zheng, Q. Jiang, R. Bennewitz, A. del Campo, Molecular stiffness cues of an interpenetrating network hydrogel for cell adhesion, Materals Today Bio, 2022, 15, 100323.

8. Y. Zheng#, M. K.L. Han#, R.g Zhao#, J. Blass#, J. Zhang, D.W. Zhou, J. Colard-Itté, D. Dattler, A. Çolak, M. Hoth, A. J. García, B. Qu, R. Bennewitz, N. Giuseppone, A. del Campo*, Optoregulated force application to cellular receptors using molecular motors, Nat. Commun. 2021, 12, 3580.

9. L. Yang, S. Dong, W. Zhou, Q. Wu, Y. Zheng, J.Cui*, Calenderable supramolecular perfluorogels for facile fabrication of slippery coatings, Chem. Eng. J. 2021, 127901.

10. J. Feng, Y. Zheng, S. Bhusari, M. Villiou, S. Pearson, A. del Campo*, Printed degradable optical waveguides for guiding light into tissue, Adv. Funct. Mater. 2020, 2004327.

11. Y. Zheng*, Z. Chen, Q. Jiang, J. Feng, S. Wu and A. del Campo*, Near-infrared-light regulated angiogenesis in a 4D hydrogel, Nanoscale, 2020, 12, 13654.

12. F. Puza, Y. Zheng*, L. Han, L. Xue and J.Cui*, Physical entanglement hydrogels: ultrahigh water content but good toughness and stretchability, Polym. Chem., 2020, 11, 2339.

13. L. Xue, X. Xiong, B. P. Krishnan, F. Puza, S. Wang, Y. Zheng*, J. Cui*, Light-regulated growth from dynamic swollen substrates for making rough surfaces, Nat. Commun.2020, 11, 963.

14. L. Han^#,Y. Zheng^#, H. Luo^#, J. Feng, R. Engstler, L. Xue, G. Jing*, X. Deng*, A. del Campo, J. Cui*, Macroscopic self-evolution of dynamic hydrogels to create hollow interiors, Angew. Chem. Int. Ed., 2019, 59, 5611.

Before joining ShanghaiTech:

Y. Zheng*, M. Han, Q. Jiang, J. Feng, Bin. Li, A. del Campo, “4D hydrogels for dynamic cell culture with orthogonal, wavelength-regulated stiffening and cell adhesiveness”, Mater. Horiz. 2019, 20, 111-116.
Y. Zheng, A. Farrukh, A. del Campo “Optoregulated Biointerfaces to Trigger Cellular Responses”, Langmuir, 2018, 34, 48,14459.
Y. Zheng*, D. Wang, J. Cui, M. Mezger, G. K. Auernhammer, K. Koynov, H.-J. Butt, T. Ikeda, “Redox-Responsive and Thermoresponsive Supramolecular Nanosheet Gels with High Young's Moduli”, Macromol. Rapid Commun. 2018, 39, 1800282.
Y. Zheng, X. Liu, J. Xu, H. Zhao, X. Hou, J. Cui “Thermo-responsive mobile interfaces with switchable wettability, optical properties, and penetrability”, ACS Appl. Mat. Interfaces, 2017, 9, 35483-35491.
Z.-S. Wu, Y. Zheng, S. Zheng, S. Wang, C. Sun, K. Parvez, T. Ikeda, X. Bao, K. Muellen, X. Feng, “Stacked-Layer Heterostructure Films of 2D Thiophene Nanosheets and Graphene for High-Rate All-Solid-State Pseudocapacitors with Enhanced Volumetric Capacitance.” Adv. Mater., 2017, 29, 1602960.
Y. Zheng, J. Cui, T. Ikeda “Click functionalization of phenyl-capped bithiophene on azide-terminated self-assembled monolayers”, Applied Surface Science, 2015, 355, 213-217.
Y. Zheng, H. Zhou, D. Liu, F. George, W. Manfred; K. Kaloian, M. Mezger, H.-J. Butt, T. Ikeda, “Thiophene Supramolecular Nanosheet”, Angew. Chem. Int. Ed., 2013, 52, 4845-4848.
Y. Zheng, D. Liu, H.-J. Butt, T. Ikeda, “Synthesis and Properties of Phenyl-capped Cyclohexyl[c]-oligothiophenes”, Synth. Met., 2013, 181, 1-9.
Y. Zheng, J. Cui, J. Zheng, X. Wan, “Near-infrared Electrochromic and Chiroptical Switching Polymers: Synthesis and Characterization of Helical Poly(N-propargylamides) Carrying Anthraquinone Imide Moieties in Side Chains”, J. Mater. Chem., 2010, 20, 5915-5922.
Y. Zheng, K. Yao, J. Lee, D. Chandler, J. Wang, C. Wang, F. Chu, C. Tang, “Well-Defined Renewable Polymers Derived from Gum Rosin”, Macromolecules, 2010, 43, 5922-5924.
Y. Zheng, J. Zheng, L. Dou, W. Qiao, X. Wan, “Synthesis and Characterization of a Novel kind of Near-infrared Electrochromic Polymers Containing an Anthraquinone Imide Group and Ionic Moieties”, J. Mater. Chem., 2009, 19, 8470-8477.